We conclude that chronic application of shear stress reduces endothelial permeability to macromolecules by a PI3K-NO-cGMP-dependent mechanism. Since atherosclerosis can be triggered by excessive entry of plasma macromolecules into the arterial wall, the phenomenon may help explain the atheroprotective effects of shear and NO.
CiteULike: Acute and chronic exposure to shear stress have opposite effects on endothelial permeability to macromolecules: "Warboys, C. M., Eric Berson, R., Mann, G. E., Pearson, J. D., and Weinberg, P. D. (2010). Acute and chronic exposure to shear stress have opposite effects on endothelial permeability to macromolecules. Am J Physiol Heart Circ Physiol, 298(6):H1850-1856."
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