The drug MDMA inhibits mitochondrial complex I activity in mice: a possible mechanism underlying neurotoxicity

Inhibition of mitochondrial complex I following MDMA could be the source of free radicals responsible for oxidative stress and the consequent neurotoxicity of this drug in mice.

CiteULike: Methylenedioxymethamphetamine inhibits mitochondrial complex I activity in mice: a possible mechanism underlying neurotoxicity: "Puerta, E., Hervias, I., Goñi-Allo, B., Zhang, S. F., Jordán, J., Starkov, A. A., and Aguirre, N. (2010). Methylenedioxymethamphetamine inhibits mitochondrial complex i activity in mice: a possible mechanism underlying neurotoxicity. British Journal of Pharmacology, 9999(9999)."