Changes in the ornithine cycle following ionising radiation cause a cytotoxic conditioning of the culture medium of H35 hepatoma cells.

We have suggested that a number of symptoms related to environmental illnesses may be influenced by ammonia levels from impairment of the urea cycle from alterations in homocysteinemia and Nrf2 regulations. A new study shows how one environmental exposure makes "a dramatic change in the ornithine (urea) cycle components after the irradiation. A strong decrease in medium arginine is accompanied with parallel increases in ornithine, citrulline and ammonia. The high level of ammonia appears to be largely responsible for the observed cytotoxicity."


CiteULike: Changes in the ornithine cycle following ionising radiation cause a cytotoxic conditioning of the culture medium of H35 hepatoma cells.: "van Rijn, J., van den Berg, J., Teerlink, T., Kruyt, F. A., Schor, D. S., Renardel de Lavalette, A. C., van den Berg, T. K., Jakobs, C., and Slotman, B. J. (2003). Changes in the ornithine cycle following ionising radiation cause a cytotoxic conditioning of the culture medium of h35 hepatoma cells. British journal of cancer, 88(3):447-454."