Stress Protein Can Modulate Inflammatory Responses to Bacterial Component

This is one of the first studies that demonstrates that HSP70 overexpression is upregulated by stress and toxic chemicals can prevent the LPS-induced increase in TNF-alpha and IL-6 levels in rats.

Notes:

• HSP70 has recently been suggested as a possible biomarker for CFS.
• Tregs with suppressive effects have higher HSP70.
• One study showed that a hot bath may induce an elevated expression of HSP70 in certain immune cells.  

Past Related Posts:

• Elevating Tregs and Heat Shock Proteins in EI - The Role of Food and Exercise
• Protein inhibitor helps rid brain of toxic tau protein - You can get too much too!

Dokladny, K., Lobb, R., Wharton, W., Ma, T. Y., and Moseley, P. L. (2010). Lps-induced cytokine levels are repressed by elevated expression of hsp70 in rats: possible role of nf-kappab. Cell stress & chaperones, 15(2):153-163. http://www.citeulike.org/user/HEIRS/article/5006779
Oehler, R., Pusch, E., Zellner, M., Dungel, P., Hergovics, N., Homoncik, M., Eliasen, M. M., Brabec, M., and Roth, E. (2001). Cell type-specific variations in the induction of hsp70 in human leukocytes by feverlike whole body hyperthermia. Cell stress & chaperones, 6(4):306-315. http://www.citeulike.org/user/HEIRS/article/6637637