Background: It has been proposed that environmental pollutants may dysregulate Treg suppressive function and may therefore contribute to environmental illness.
"The enterocolitis in the Il10–/– mice is largely attributed to dysfunctional Tregs. As in many other models of intestinal inflammation, the inflammatory response in the intestinal mucosa in this model of colitis depends on luminal bacteria and/or their inflammatory components....In addition, this author reported that mice that were null for both IL10 and TLR4 have increased inflammation and is similar to the findings of increased inflammation from Helicobacter in Il10 -/- and TLR4 -/- animals. These findings suggest a positive role of TLR4 on the regulatory function of Tregs in intestinal inflammation."
González-Navajas, J. M., Fine, S., Law, J., Datta, S. K., Nguyen, K. P., Yu, M., Corr, M., Katakura, K., Eckman, L., Lee, J., and Raz, E. (2010). Tlr4 signaling in effector cd4+ t cells regulates tcr activation and experimental colitis in mice. Journal of Clinical Investigation.
http://www.citeulike.org/user/HEIRS/article/6488590?show_msg=already_posted
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