Parkinsons Model Identifies Protein & Mitochondria Metabolic Dysruptions

In Parkinson's disease model, while oxygen consumption is similar to control lines, PD lines demonstrate reduced SIRT1 phosphorylation, lower PGC-1a levels and increased NF-kabbaB activation. Results suggest altered aerobic metabolism and mitochondrial respiration.

Mitochondrial Respiration and Respiration Associated Proteins in Cell Lines Created through Parkinson's Subject Mitochondrial Transfer.: "Raquel Esteves, A., Lu, J., Rodova, M., Onyango, I., Lezi, E., Dubinsky, R., Lyons, K. E., Pahwa, R., Burns, J. M., Cardoso, S. M., and Swerdlow, R. H. (2010). Mitochondrial respiration and respiration associated proteins in cell lines created through parkinson's subject mitochondrial transfer. Journal of neurochemistry."