Comment: Alterations in the levels of physiological transporters that move medications from one place to another may influence their distribution - and therefore can contribute to their side effects or why they do not achieve the expected therapeutics benefits.
Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption.: "Uhr, M., Grauer, M. T., and Holsboer, F. (2003). Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) p-glycoprotein gene disruption. Biological psychiatry, 54(8):840-846."
No comments:
Post a Comment