Hyperammonemia significantly alters the rhythm of spontaneous ambulatory activity, reducing strongly ambulatory counts and slightly average velocity during the night (the active phase) but not during the day, resulting in altered circadian rhythms. In contrast, hyperammonemia did not affect wheel running at all, indicating that it affects spontaneous but not voluntary activity. Vertical activity was affected only very slightly, indicating that hyperammonemia does not induce anxiety. Hyperammonemia abolished completely the circadian rhythm of corticosteroid hormones in plasma, completely eliminating the peaks of cortisol and corticosterone present in control rats at the start of the dark period.
Chronic hyperammonemia alters the circadian rhythms of corticosteroid hormone levels and of motor activity in rats.: "Ahabrach, H., Piedrafita, B., Ayad, A., El Mlili, N., Errami, M., Felipo, V., and Llansola, M. (2009). Chronic hyperammonemia alters the circadian rhythms of corticosteroid hormone levels and of motor activity in rats. Journal of neuroscience research."
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