Inactivation of GSK-3β by Metallothionein Prevents Diabetes-Related Changes in Cardiac Energy Metabolism, Inflammation, Nitrosative Damage, and Remodeling

Background: GSk-3b has been shown to be an "on-off" switch for the Nrf2 antioxidant system. The following article discusses how metallothionein ( MT)prevent changes in heart function from diabetes by inactivation of this protein. MT which can be regulated by Nrf2 also have also been demonstrated to abrogate other changes in the mitochondria from O2 production and the downregulation of PGC-1a and its downstream targets.


CiteULike: Inactivation of GSK-3β by Metallothionein Prevents Diabetes-Related Changes in Cardiac Energy Metabolism, Inflammation, Nitrosative Damage, and Remodeling: "Wang, Y., Feng, W., Xue, W., Tan, Y., Hein, D. W., Li, X.-K., and Cai, L. (2009). Inactivation of gsk-3β by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling. Diabetes, 58(6):1391-1402."