Background: A report last year suggests that loss of regulatory T cells may contribute to chemical sensitivity from environmental exposures. As this author describes, "the transcription factor FOXP3 is crucial for the suppressive activity of Tregs and is considered the most specific marker for this population.....The results of his most recent findings show that "only complete demethylation of the conserved FOXP3 promoter region support stable long term FOXP3 expression and a committed Treg phenotype in humans."
CiteULike: FOXP3 Promoter Demethylation Reveals the Committed Treg Population in Humans: "Janson, P. C. J., Winerdal, M. E., Marits, P., Thörn, M., Ohlsson, R., and Winqvist, O. (2008). Foxp3 promoter demethylation reveals the committed treg population in humans. PLoS ONE, 3(2):e1612+."
Mićović, V., Vojniković, B., Bulog, A., Coklo, M., Malatestinić, D., and Mrakovcić-Sutić, I. (2009). Regulatory t cells (tregs) monitoring in environmental diseases. Collegium antropologicum, 33(3):743-746.http://www.citeulike.org/group/6057/article/6090770
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