"Inflamed adipocytes produce much more TNF-a in inflamed adipose tissue through TLR4 signaling. It has been known for a long time that adipocytes and macrophages produce TNF-a, an important inflammatory, but this is the first study to show that pathway steps involved and that adipocytes contribute a greater amount that immune cells in adipose tissue. Because adipocytes are a primary source of different adipose hormones TNF-a made influence the expression of their genes. "
CiteULike: Signaling pathways involved in LPS induced TNFalpha production in human adipocytes: "Hoareau, L., Bencharif, K., Rondeau, P., Murumalla, R., Ravanan, P., Tallet, F., Delarue, P., Cesari, M., Roche, R., and Festy, F. (2010). Signaling pathways involved in lps induced tnfalpha production in human adipocytes. Journal of Inflammation, 7(1):1+."
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