Endotoxin Inactivates Glutamine Synthetase and Impairs Ammonia Elimination in Rats

"In conclusion, LPS impairs hepatic ammonia detoxification by both downregulation of GS and its inactivation because of tyrosine nitration. The resulting defect of perivenous scavenger cell function with regard to ammonia elimination may contribute to sepsis-induced development of hyperammonemia in patients who have cirrhosis."

Görg, B., Wettstein, M., Metzger, S., Schliess, F., and Häussinger, D. (2005). Lipopolysaccharide-induced tyrosine nitration and inactivation of hepatic glutamine synthetase in the rat. Hepatology (Baltimore, Md.), 41(5):1065-1073.