Thursday, December 10, 2009

Activation of Glycogen Synthase Kinase-3{beta} Is Required for Hyperdopamine and D2 Receptor-Mediated Inhibition of Synaptic NMDA Receptor Function in the Rat Prefrontal Cortex

Background: GSK-3B is an off/on switch for Nrf2.

Title: Activation of glycogen synthase kinase-3beta is required for hyperdopamine and d2 receptor-mediated inhibition of synaptic nmda receptor function in the rat prefrontal cortex.

Summary: GSK-3beta is required for the hyperdopamine/D2 receptor-mediated inhibition of NMDA receptors in the prefrontal neurons and these actions may underlie D2 receptor-mediated psychostimulant effects and hyperdopamine-dependent behaviors in the brain.

Li, Y.-C., Xi, D., Roman, J., Huang, Y.-Q., and Gao, W.-J. (2009). Activation of glycogen synthase kinase-3beta is required for hyperdopamine and d2 receptor-mediated inhibition of synaptic nmda receptor function in the rat prefrontal cortex. 29(49):15551-15563. http://www.citeulike.org/user/HEIRS/article/6347607

Cuadrado, A., Moreno-Murciano, P., and Pedraza-Chaverri, J. (2009). The transcription factor nrf2 as a new therapeutic target in parkinson's disease. Expert Opinion on Therapeutic Targets, 13(3):319-329. http://www.citeulike.org/user/HEIRS/article/4116731



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