Cigarette Smoke Generates Reactive Species Through TLR4/NADPH Oxidase Pathway

HEIRS Environmental Illness Research Blog: Why Endotoxin Can Increase Pain,Chemical and Mold Sensitivity and Causes Sickness Behavior!

Summary: These results demonstrated that CSE-induced ROS generation was mediated through the TLR4/MyD88/TRAF6/c-Src/NADPH oxidase pathway, in turn initiated the activation of MAPKs and NF-kappaB, and ultimately induced COX-2/PGE(2)/IL-6-dependent airway inflammation.


Induction of cox-2/pge(2)/il-6 is crucial for cigarette smoke extract-induced airway inflammation: Role of tlr4-dependent nadph oxidase activation. http://www.citeulike.org/user/HEIRS/article/6076362