TNF-alpha-mediated reduction in PGC-1alpha may impair skeletal muscle function after cigarette smoke exposure

Summary: "this data suggest that in response to smoke exposure, TNF-alpha-mediated down-regulation of PGC-1alpha may be a key step leading to vascular and myocyte dysfunction, effects that are more evident in oxidative than glycolytic skeletal muscles."

Citation: Tang, K., Wagner, P. D., and Breen, E. C. (2009). Tnf-alpha-mediated reduction in pgc-1alpha may impair skeletal muscle function after cigarette smoke exposure. Journal of Cellular Physiology, 9999(9999):n/a+. http://www.citeulike.org/user/HEIRS/article/6018324