Study: Potentiation of methamphetamine neurotoxicity by intrastriatal lipopolysaccharide administration

Title: Potentiation of methamphetamine neurotoxicity by intrastriatal lipopolysaccharide administration.

Summary: "neuroinflammation, oxidative stress, and pro-apoptotic changes in the striatum were more accentuated with combined treatment of LPS and MA compared to either treatment alone. In addition, it is important that cytoplasmic accumulation of alpha-synuclein was observed in the substantia nigra of mice treated with LPS plus MA, and that L-Dopa treatment significantly attenuated behavioral changes and dopaminergic deficits induced by LPS plus MA."

Jung, B. D. D., Shin, E.-J. J., Nguyen, X.-K. T. K., Jin, C.-H. H., Bach, J.-H. H., Park, S. J. J., Nah, S.-Y. Y., Wie, M.-B. B., Bing, G., and Kim, H.-C. C. (2009). Potentiation of methamphetamine neurotoxicity by intrastriatal lipopolysaccharide administration. Neurochemistry international. http://www.citeulike.org/user/HEIRS/article/6003313