Oxidative stress-induced necrotic cell death via mitochondira-dependent burst of reactive oxygen species.

Summary: "The inhibition of mitochondrial hyperpolarization by diphenylene iodonium or rotenone, potent inhibitors of mitochondrial respiratory chain complex I, also resulted in reduced ROS production and subsequent neuronal cell death in vitro and in vivo. The inhibition of mitochondrial hyperpolarization can protect neuronal cells from oxidative stress-induced necrotic cell death, suggesting a novel method of therapeutic intervention in oxidative stress-induced neurological disease."



Choi, K., Kim, J., Kim, G. W., and Choi, C. (2009). Oxidative stress-induced necrotic cell death via mitochondira-dependent burst of reactive oxygen species. Current neurovascular research. http://www.citeulike.org/user/HEIRS/article/5918128