Heightened endoplasmic reticulum stress in copd lungs: The role of nrf2-regulated proteasomal activity.

Title: Heightened endoplasmic reticulum stress in copd lungs: The role of nrf2-regulated proteasomal activity.

Summary: "Impaired Nrf2 signaling causes significant decline in proteasomal activity and heightens ER stress response in lungs of patients with COPD and CS-exposed mice."

Malhotra, D., Thimmulappa, R., Vij, N., Navas-Acien, A., Sussan, T., Merali, S., Zhang, L., Kelsen, S. G., Myers, A., Wise, R., Tuder, R., and Biswal, S. (2009). Heightened endoplasmic reticulum stress in copd lungs: The role of nrf2-regulated proteasomal activity. American journal of respiratory and critical care medicine.