Elevated insular glutamate in fibromyalgia is associated with experimental pain.

Title: Elevated insular glutamate in fibromyalgia is associated with experimental pain.

Summary: The author concluded "enhanced glutamatergic neurotransmission resulting from higher concentrations of Glu within the posterior insula may play a role in the pathophysiology of FM and other central pain augmentation syndromes."



Harris, R. E., Sundgren, P. C., Craig, A. D., Kirshenbaum, E., Sen, A., Napadow, V., and Clauw, D. J. (2009). Elevated insular glutamate in fibromyalgia is associated with experimental pain. Arthritis & Rheumatism, 60(10):3146-3152.