Background: At normal levels, numerous studies have shown that caffeic acid which is an antioxidant helps prevent acute immune and inflammatory responses and in found in honey bee hive propolis. (Wipedia)
Title: The ultrastructural and biochemical evidences of the beneficial effects of chronic caffeic acid phenethyl ester and melatonin administration on brain and cerebellum of aged rats.
Summary: Study shows benefits of "supplemental administration of caffeic acid phenethyl ester and melatonin is beneficial in delaying age-related cellular damage in nervous system."
Citation: Mukaddes Eşrefoğlu, Mehmet Gül, Burhan Ateş, İsmet Yılmaz (2009). The ultrastructural and biochemical evidences of the beneficial effects of chronic caffeic acid phenethyl ester and melatonin administration on brain and cerebellum of aged rats. Fundamental & Clinical Pharmacology, 9999(9999). http://www.citeulike.org/user/HEIRS/article/5917868
Other References: Natarajan, K., Singh, S., Burke, T. R., Grunberger, D., and Aggarwal, B. B. (1996). Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor nf-kappa b. Proceedings of the National Academy of Sciences of the United States of America, 93(17):9090-9095.
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