Sunday, September 6, 2009

SIRT1, PGC-1a and Exercise

Dumke et al demonstrated that successive bouts of exercise in normal already trained subjects increases expression of cytochrome c, citrate synthase, PGC-1a and SIRT1. This is the first study that shows an increase of SIRT1 with acute and chronic exercise.


Dumke, C. L., Mark Davis, J., Angela Murphy, E., Nieman, D. C., Carmichael, M. D., Quindry, J. C., Travis Triplett, N., Utter, A. C., Gross Gowin, S. J., Henson, D. A., McAnulty, S. R., and McAnulty, L. S. (2009). Successive bouts of cycling stimulates genes associated with mitochondrial biogenesis. European journal of applied physiology. http://www.citeulike.org/user/HEIRS/article/5415657

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