Loss of Nrf2 Signaling with ER Stress

We have explained that several factors can lead to impairment of Nrf2 including nutrition, actions of other proteins that interact with it, genetic factors, aging, endoplasmic reticulum stress, etc.  On the other hand, ER stress is characterized by the accumulation of misfolded proteins, altered Ca2+ regulation and up-regulations of other proteins including GRP78. Consistent activation of TRPV1, as well as, dopamine exposure has been known to lead to endoplasmic reticulum stress (Chen). This is a link to a slide presentation that was written by a co-worker of Tory Hagan's from Oregon State University about the Loss of Nrf2 signaling from ER stress.  We have cited Dr. Hagan's work before in other blogs in reference to Nrf2 and its decline in function from aging. (Fallahi)

Fallahi, A., Dixon, B., and Hagen, T. Loss of nrf2 dependant signaling following induction of endoplasmic reticulum stress. Visual Presentation, Oregon State University. http://www.citeulike.org/user/HEIRS/article/5730536
Chen, G. A. N. G., Bower, K. A., Ma, C., Fang, S., Thiele, C. J., and Luo, J. I. A. (2004). Glycogen synthase kinase 3beta (gsk3beta) mediates 6-hydroxydopamine-induced neuronal death. FASEB J., 18(10):1162-1164.  http://www.citeulike.org/user/HEIRS/article/5487100