The aryl hydrocarbon receptor (AHR), a novel regul... [Pigment Cell Melanoma Res. 2010] - PubMed result

The aryl hydrocarbon receptor (AHR), a novel regul... [Pigment Cell Melanoma Res. 2010] - PubMed result: "The aryl hydrocarbon receptor (AHR), a novel regulator of human melanogenesis."

Nrf2 Deficiency Influences Susceptibility to Stero... [Biochem Biophys Res Commun. 2010] - PubMed result

Nrf2 Deficiency Influences Susceptibility to Stero... [Biochem Biophys Res Commun. 2010] - PubMed result: "Nrf2 Deficiency Influences Susceptibility to Steroid Resistance via HDAC2 reduction"

Aging Reversed in Mice - ABC News

"Scientists have turned back the clock in mice they engineered to age faster than normal, an advance they suggest is the first time aging in mice has been reversed"

Read more: Aging Reversed in Mice - ABC News:

Growth-Factor Gel Shows Promise As Hearing-Loss Treatment

"A new treatment has been developed for sudden sensorineural hearing loss (SSHL), a condition that causes deafness in 40,000 Americans each year, usually in early middle-age."

Read more: Growth-Factor Gel Shows Promise As Hearing-Loss Treatment:

HIF-2alpha, but not HIF-1alpha, promotes iron abso... [J Clin Invest. 2009] - PubMed result

HIF-2alpha, but not HIF-1alpha, promotes iron abso... [J Clin Invest. 2009] - PubMed result: "whereas HIF-2alpha played a crucial role in maintaining iron balance in the organism by directly regulating the transcription of the gene encoding divalent metal transporter 1 (DMT1), the principal intestinal iron transporter"

Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation

Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation: "HIF-2α (but not HIF-1α) directly activates the expression of Oct4, a critical transcription factor regulating stem cell maintenance (28), as well as the red blood cell cytokine erythropoietin (29)."

The Journal of clinical investigation, Vol. 120, No. 8. (2 August 2010), pp. 2699-2714.
http://www.citeulike.org/user/HEIRS/article/8311046

PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types.

"HIF2α acts downstream of PGC-1α as a key regulator of a muscle fiber-type program and the adaptive response to exercise."

Proceedings of the National Academy of Sciences of the United States of America (24 November 2010) http://www.citeulike.org/user/HEIRS/article/8311034

Health and Environmental Illness Research Blog: PGC-1a , Cold, MCK, Myogenesis and Nrf2 and Environmental Illness?!

Combining NO release W/ anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a MPTP model of Parkinson's disease

Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

Role of oxidative stress on diesel-enhanced influenza infection in mice

"exposure to DE during an influenza infection polarizes the local immune responses to an IL-4 dominated profile in association with increased viral disease, and some aspects of this effect can be reversed with antioxidants."

Read abstract: CiteULike: Role of oxidative stress on diesel-enhanced influenza infection in mice:

N-acetylcysteine prevents loss of dopaminergic neurons in the EAAC1−/− mouse

"These findings suggest that the EAAC1−/− mouse may be a useful model of the chronic neuronal oxidative stress that occurs in PD. The salutary effects of N-acetylcysteine in this mouse model provide an impetus for clinical evaluation of glutathione repletion in PD. ANN NEUROL 2010"


Read more: CiteULike: N-acetylcysteine prevents loss of dopaminergic neurons in the EAAC1−/− mouse:

Astrocyte Oxidative Metabolism and Metabolite Trafficking after Fluid Percussion Brain Injury in Adult Rats

"integral protective role for astrocytes in maintaining metabolic function following TBI-induced impairments in glucose metabolism"

Read more: Mary Ann Liebert, Inc. - Journal of Neurotrauma - 0(0)::

Blueberry Shows Potential Benefits Against Hepatic Fibrosis~!

"Blueberry can significantly inhibit the proliferation and activation of HSC and reduce the synthesis of extra-cellular matrix. It may have potential preventive and protective effects on hepatic fibrosis. The mechanism may be related to an elevated expression of HO-1 through the Nrf2 pathway."

CiteULike: [Effects of blueberry on the proliferation and activation of hepatic stellate cell and its mechanism.]:

The role of the antioxidant and longevity-promotin... [Curr Opin Clin Nutr Metab Care. 2010] - PubMed result

The role of the antioxidant and longevity-promotin... [Curr Opin Clin Nutr Metab Care. 2010] - PubMed result: "The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation."

Canaries in the coal mine: a cross-species analysis of the plurality of obesity epidemics — Proceedings B

Canaries in the coal mine: a cross-species analysis of the plurality of obesity epidemics — Proceedings B: "aetiology of increasing body weight may involve several as-of-yet unidentified and/or poorly understood factors (e.g. viral pathogens, epigenetic factors)."

Dioxin toxicity in vivo results from an increase i... [PLoS One. 2010] - PubMed result

Dioxin toxicity in vivo results from an increase i... [PLoS One. 2010] - PubMed result: "Dioxin toxicity in vivo results from an increase in the dioxin-independent transcriptional activity of the aryl hydrocarbon receptor."

Airborne fine particulate matter induced pulmonary inflammation as well as oxidative stress in neonate rats.

"Study demonstrated acute exposure to fine PM induced airway inflammation as well as increased oxidative stress in addition to its direct toxic effect on airway epithelium cells."

Read more: CiteULike: Airborne fine particulate matter induced pulmonary inflammation as well as oxidative stress in neonate rats.:

Effectiveness of dust control methods for crystall... [J Occup Environ Hyg. 2010] - PubMed result

"Effectiveness of dust control methods for crystalline silica and respirable suspended particulate matter exposure during manual concrete surface grinding"

Read more:Effectiveness of dust control methods for crystall... [J Occup Environ Hyg. 2010] - PubMed result:

Research proves 'gender-bending' chemicals affect reproduction

Research proves 'gender-bending' chemicals affect reproduction

Marked changes in endogenous antioxidant expressio... [Free Radic Biol Med. 2010] - PubMed result

: "Marked changes in endogenous antioxidant expression precede vitamin A-, C-, and E-protectable, radiation-induced reductions in small intestinal nutrient transport."

Read more: Marked changes in endogenous antioxidant expressio... [Free Radic Biol Med. 2010] - PubMed result

Introducing the 'A-Train'

Introducing the 'A-Train'

Genetic Mechanisms of Coffee Extract Protection in a Caenorhabditis elegans Model of {beta}-Amyloid Peptide Toxicity [Gene expression]

Genetic Mechanisms of Coffee Extract Protection in a Caenorhabditis elegans Model of {beta}-Amyloid Peptide Toxicity [Gene expression]

Hsp90-INrf2(Keap1) Interaction and Nrf2 Activation [Gene Regulation]

Hsp90-INrf2(Keap1) Interaction and Nrf2 Activation [Gene Regulation]

SKN-1/Nrf2 Inhibits Dopamine Neuron Degeneration in a Caenorhabditis elegans Model of Methylmercury Toxicity

SKN-1/Nrf2 Inhibits Dopamine Neuron Degeneration in a Caenorhabditis elegans Model of Methylmercury Toxicity

microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease

microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease

Reactivity of hydrogen sulfide with peroxynitrite and other oxidants of biological interest.

CiteULike: Reactivity of hydrogen sulfide with peroxynitrite and other oxidants of biological interest.: "Considering the low tissue concentrations of endogenous hydrogen sulfide, direct reactions with oxidants probably cannot completely account for its protective effects."

Resveratrol recruits rat muscle microvasculature via a nitric oxide-dependent mechanism that is blocked by tumor necrosis factor-{alpha}

Resveratrol recruits rat muscle microvasculature via a nitric oxide-dependent mechanism that is blocked by tumor necrosis factor-{alpha}

Essential role of ER-{alpha}-dependent NO production in resveratrol-mediated inhibition of restenosis

Essential role of ER-{alpha}-dependent NO production in resveratrol-mediated inhibition of restenosis

Chronic cigarette smoking causes hypertension, increased oxidative stress, impaired NO bioavailability, endothelial dysfunction, and cardiac remodeling in mice.

Chronic cigarette smoking causes hypertension, increased oxidative stress, impaired NO bioavailability, endothelial dysfunction, and cardiac remodeling in mice.

Advanced Oxidation Protein Products Induce Inflammatory Response and Insulin Resistance in Cultured Adipocytes via Induction of Endoplasmic Reticulum Stress

Advanced Oxidation Protein Products Induce Inflammatory Response and Insulin Resistance in Cultured Adipocytes via Induction of Endoplasmic Reticulum Stress

Evidence for enhanced tissue factor expression in age-related macular degeneration

Evidence for enhanced tissue factor expression in age-related macular degeneration

Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden

Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden

Lack of interleukin-1 type 1 receptor enhances the accumulation of mutant huntingtin in the striatum and exacerbates the neurological phenotypes of Huntington's disease mice

Lack of interleukin-1 type 1 receptor enhances the accumulation of mutant huntingtin in the striatum and exacerbates the neurological phenotypes of Huntington's disease mice

Simultaneous exposure of non-diabetics to high levels of dioxins and mercury increases their risk of insulin resistance.

"simultaneous exposure to dioxins and mercury heightens the risk of insulin resistance more than does individual exposure."


Read abstract: CiteULike: Simultaneous exposure of non-diabetics to high levels of dioxins and mercury increases their risk of insulin resistance.:

CiteULike: Environmentally induced oxidative stress in aquatic animals.

CiteULike: Environmentally induced oxidative stress in aquatic animals.: "The role of transition metal ions, such as copper, chromium, mercury and arsenic, and pesticides, namely insecticides, herbicides, and fungicides along with oil products in induction of oxidative stress is highlighted"

Epigenetic modifications and human pathologies: ca... [Proc Nutr Soc. 2010] - PubMed result

Epigenetic modifications and human pathologies: ca... [Proc Nutr Soc. 2010] - PubMed result: "Epigenetic modifications and human pathologies: cancer and CVD."

Microbial and Host Cells Acquire Enhanced Oxidant-... [Arch Biochem Biophys. 2010] - PubMed result

Microbial and Host Cells Acquire Enhanced Oxidant-... [Arch Biochem Biophys. 2010] - PubMed result: "Microbial and Host Cells Acquire Enhanced Oxidant-Scavenging Abilities by Binding Polyphenols."

Is Bear Education Your Flavor? A 10$ donation may turn into 20, 000 if the NABC wins!

Support bear education worldwide through a program designed for students. 

Donate now or learn more at North American Bear Center link.

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$10.00 Donation to the Wildlife Research Institute Can Win Them $20,000 More!

Support wildlife and bear research. Thanks!

Click here to donate to Wildlife Research Center !

CD4+CD25+Foxp3+ Regulatory T Cells Depletion May A... [PLoS One. 2010] - PubMed result

CD4+CD25+Foxp3+ Regulatory T Cells Depletion May A... [PLoS One. 2010] - PubMed result: "CD4+CD25+Foxp3+ Regulatory T Cells Depletion May Attenuate the Development of Silica-Induced Lung Fibrosis in Mice."

Dust Storm Particles Induce a Broad Toxicological Effects in Skin

"Asian dust particles can exert toxicological effects on human skin through the activation of the cellular detoxification system, the production of pro-inflammatory and immunomodulatory cytokines, and changes in the expression of proteins essential in normal epidermal differentiation."

Read more: Asian Dust Storm Particles Induce a Broad Toxicolo... [Toxicol Lett. 2010] - PubMed result:

An endogenous aryl hydrocarbon receptor ligand act... [Proc Natl Acad Sci U S A. 2010] - PubMed result

An endogenous aryl hydrocarbon receptor ligand act... [Proc Natl Acad Sci U S A. 2010] - PubMed result: "An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis"

Small Intestinal Bacterial Overgrowth in Nonalcoholic Steatohepatitis: Association with Toll-Like Receptor 4 Expression and Plasma Levels of Interleukin 8.

"NASH patients have a higher prevalence of small intestinal bacterial overgrowth which is associated with enhanced expression of TLR-4 and release of IL-8. SIBO may have an important role in NASH through interactions with TLR-4 and induction of the pro-inflammatory cytokine, IL-8."

Read more: CiteULike: Small Intestinal Bacterial Overgrowth in Nonalcoholic Steatohepatitis: Association with Toll-Like Receptor 4 Expression and Plasma Levels of Interleukin 8.:

CNS glial cells in oro-facial pain with injury, infection and inflammation

"nerve injury and oro-facial infection/inflammation induced CNS glial activation, but in a completely different pattern, which suggests a remarkable plasticity of glial cells in response to dynamic changes in their microenvironment and different potential involvement of this non-neuronal cell population in pathological pain development."

Read more: CiteULike: Distinctive response of CNS glial cells in oro-facial pain associated with injury, infection and inflammation:

Broccoli Compound Activates Heat Shock Proteins in Addition to Nrf2

"heat shock response by SFN, in addition to the antioxidant response mediated by the Keap1-Nrf2 pathway, may contribute to cytoprotection."

Read more: CiteULike: Sulforaphane Activates Heat Shock Response and Enhances Proteasome Activity through Up-regulation of Hsp27:

Support Ely Minnesota Schools to win GRANT -- It is FREE and Quick to Vote!

Support the Ely Schools: We are voting for Ely schools to win a grant to buy new educational technology equipment that is badly needed. Please help by voting -- it is free and takes just a few seconds....This is a small rural school that had needed substantial upgrades for several years! Thanks bunches! We made it easy the link is below...!!


Ely Esy, Ely, MN 55731

Interleukin Genetics And The University Of North Carolina At Chapel Hill Announce Presentation Of Additional Clinical Study Findings On Osteoarthritis

Interleukin Genetics And The University Of North Carolina At Chapel Hill Announce Presentation Of Additional Clinical Study Findings On Osteoarthritis: "Interleukin Genetics, Inc. (Pink Sheets: ILIU) and the Thurston Arthritis Research Center at the University of North Carolina at Chapel Hill"

Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.

CiteULike: Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.: "toxicants acting through AhR to target xenobiotic efflux transporters at the blood-brain barrier and thus reduce brain accumulation of CNS-acting therapeutic drugs"

Tregs interfere with glutathione metabolism in dendritic cells and T cells.

CiteULike: Regulatory T cells interfere with glutathione metabolism in dendritic cells and T cells.: "these data provide novel insights into modulation of sulfur-based redox metabolism by Tregs leading to suppression of T cell activation and proliferation"

Study: Polar bears could be saved by snow geese -

"Good news for the polar bear! A new study finds that the Arctic animal, threatened with extinction by climate change, may be able to survive by eating snow goose eggs, without harming the geese"


Read more:Study: Polar bears could be saved by snow geese - Green House - USATODAY.com:

MIcrobiota Health Regulates Il-10 and Resistance to LPS in the Gut~!

Comment: This supports the idea it is probably not a good thing to mess up the gut in wildlife in addition to people!

"these results demonstrate that the activity of LM to produce pro-inflammatory cytokines is negatively regulated through commensal microbiota-dependent IL-10 production in the large intestine."

CiteULike: Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10.:

Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival.

CiteULike: Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival.: "AMPK stimulates heme oxygenase-1 gene expression in human endothelial cells via the Nrf2/antioxidant responsive element signaling pathway."

I NEED This: UV LIght Improve Vacuum Effectiveness~!

"New research suggests that the addition of ultraviolet light to the brushing and suction of a vacuum cleaner can almost double the removal of potentially infectious microorganisms from a carpet's surface when compared to vacuuming alone."

UV Light Nearly Doubles Vacuum's Effectiveness In Reducing Carpet Microbes:

Strengthening Link Between FOXO1 and Inflammation, Insulin Resistance.

Comment: Past studies show EGCG connection. (Reiter)

"Researchers at the University of California, San Diego School of Medicine have discovered that a multi-tasking protein called FoxO1 has another important but previously unknown function: It directly interacts with macrophages, promoting an inflammatory response that can lead to insulin resistance and diabetes."


Macrophage Protein Has Major Role In Inflammation:

Related Tag: FOXO1
Supplemental Citation:
Reiter, Chad E. N., Kim, Jeong-a, and Quon, Michael J. (2010). Green Tea Polyphenol Epigallocatechin Gallate Reduces Endothelin-1 Expression and Secretion in Vascular Endothelial Cells: Roles for AMP-Activated Protein Kinase, Akt, and FOXO1. Endocrinology, 151(1):103-114.
http://www.citeulike.org/user/HEIRS/article/6087895

CiteULike: Vasoactive intestinal peptide loss leads to impaired CNS parenchymal T-cell infiltration and resistance to experimental autoimmune encephalomyelitis.

CiteULike: Vasoactive intestinal peptide loss leads to impaired CNS parenchymal T-cell infiltration and resistance to experimental autoimmune encephalomyelitis.: "VIP plays an unanticipated permissive and/or proinflammatory role in the propagation of the inflammatory response in the CNS, a finding with potential therapeutic relevance in autoimmune neuroinflammatory diseases such as multiple sclerosis."

Electroacupuncture inhibits inflammation reaction ... [Evid Based Complement Alternat Med. 2011] - PubMed result

Electroacupuncture inhibits inflammation reaction ... [Evid Based Complement Alternat Med. 2011] - PubMed result: "Electroacupuncture inhibits inflammation reaction by upregulating vasoactive intestinal Peptide in rats with adjuvant-induced arthritis."

Anxiety-like behavior in the elevated-plus maze te... [Neurosci Lett. 2010] - PubMed result

Anxiety-like behavior in the elevated-plus maze te... [Neurosci Lett. 2010] - PubMed result: "Anxiety-like behavior in the elevated-plus maze tests and enhanced IL-1β, IL-6, NADPH oxidase-1, and iNOS mRNAs in the hippocampus during early stage of adjuvant arthritis in rats."

Higher proportion of fast-twitch (type II) muscle ... [Clin Physiol Funct Imaging. 2010] - PubMed result

Higher proportion of fast-twitch (type II) muscle ... [Clin Physiol Funct Imaging. 2010] - PubMed result: "Higher proportion of fast-twitch (type II) muscle fibres in idiopathic inflammatory myopathies - evident in chronic but not in untreated newly diagnosed patients."

[Effect of cigarette smoke on Tregs and Foxp3 in Asthma~!

Wow---How did I miss this?


[Effect of cigarette smoke exposure on the percent... [Zhonghua Jie He He Hu Xi Za Zhi. 2010] - PubMed result: "[Effect of cigarette smoke exposure on the percentage of CD(4)(+)CD(25)(+) regulatory T cells and the expression of transcription factor Foxp3 in asthmatic rats.]"